Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy.
نویسندگان
چکیده
T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.
منابع مشابه
T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. Objective: To investigate the T helper cells type 1 (Th1) /Th2/Th17/Treg paradigms in peripheral blood of infertile PCOS compared ...
متن کاملمروری بر نقش زیرگروه‌های لنفوسیت‌های T در پاتوژنز بیماری مولتیپل اسکلروزیس
Background and Objectives: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease of the central nervous system (CNS). Although, the contribution of various cells such as B cells, CD8+ T cells, microglia/macrophages, dendritic cells, asterocytes and mast cells in the pathogenesis of MS have been demonstrated, however, it seems that autoreactive myelin specific CD4+ T cells pla...
متن کاملThe Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy
Acceptance of the fetal semi-allograft by the mother's immune system has become the focus of intensive research. CD4+ T cells are important actors in the establishment of pregnancy. Th1/Th2 paradigm has been expanded to include CD4+ regulatory T (Treg) and T helper 17 (Th17) cells. Pregnancy hormones exert very significant modulatory properties on the maternal immune system. In this review, we ...
متن کاملT helper cell mediated-tolerance towards fetal allograft in successful pregnancy
Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release various cytokines in response to these alloantigens. On the basis of the cytokines produced, these cells can be classified in Th1, Th2 and Th17 cells. Th1 and Th17 cells, known to be responsibl...
متن کاملComparison of Th1/Th2 and Treg/Th17 ratios between wet and dry cupping therapies in Persian medicine
Objective: In Persian medicine (PM), wet-cupping therapy (WCT) is the most utilized approach. WCT is mostly done between the shoulders, which is referred to as “hejamt-e-aam” in the Persian language. CD4+T cells also refer to T helper lymphocytes play a critical role in the immune system. Naïve CD4+ T cells differentiate into at least four subsets, T helper 1 (Th1), T helper 2 (Th2), T helper 1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- American journal of reproductive immunology
دوره 63 6 شماره
صفحات -
تاریخ انتشار 2010